Table 1 Exosomal miRNAs as prognostic molecular markers

Lung cancer

miR-21

Bronchial epithelial (HBE) cells

Normal HBE cells

Angiogenesis

[88]

miR-23b-3p, miR-10b-5p and miR-21-5p

Plasmatic exosomes

Non-small cell lung cancer cells(NSCLC)

Progression, angiogenesis and metastasis

[61, 109]

miR-210

Lung adenocarcinoma

Stromal cells

Angiogenesis

[110]

miR-155/-146a

Immune cells

Immune cells

Inflammation

[111]

miR-192

A549

Endothelial cells

Bone metastasis

[112]

miR-494

Lung adenocarcinoma cells

Lymph nodes, lung cells

Pre-metastasis

[113]

Esophageal cancer(ESCC)

miR-30a

ESCC cells

/

Proliferation

[114]

Gastric cancer

miR-21

Macrophage

BGC-823

Metastasis

[115]

miR-221

Mesenchymal stem cells

HGC-27

Metastasis

[116]

Colorectal cancer(CRC)

miR-19a

CRC cells

/

Metastasis

[117]

miR-21, -192 and-221

HCT-15, SW480 and WiDr

HepG2 and A549

/

[118]

miR-23b-3p

Blood plasma isolated from CRC patients

Colon cancer cells

Inhibitor

[109]

Liver cancer

miR-122

Huh7 cells

HepG2 cells

Inhibitor

[119]

miR-223

Macrophages

Hepatocellular carcinoma cells (HuH7 and HepG2)

Inhibitor

[120]

Pancreatic cancer

miR-19b

PCa cells

Urine

Diagnosis

[121]

miR-23b-3p

PANC-1 cells

PANC-1 cells

Proliferation and metastasis

[30, 109]

miR-122-5p and miR-193b-3p

Plasma samples

Pancreatic cancer cells

Proliferation

[122]

miR-141

PCa cells

Serum

Metastasis

[100]

miR-141, miR-375

PCa cells

Serum

Metastasis

[98]

miR-145

Urine

PCa cells

Suppressor

[98]

miR-196a-5p

Urine

PCa cells

Metastasis

[123]

miR-200c-3p

Urine

PCa cells

Suppressor

[98]

miR-1246

Serum

PCa cells

Metastasis

[103]

miR-1290, miR-375

PCa cells

Plasma

Survival prognosis

[124]

Bladder cancer

Exosome-derived miR- 29c

miR-29c

BIU-87 cells

Apoptosis

[125]

Prostate cancer

miR-34a

Docetaxel-resistant PC cells

Docetaxel-resistant

Drug resistance

[126]

miR-125a

DIAPH3-silenced cells

macrophages

Proliferation

[126]

miR-141

Bone metastatic PCa cells

Bone cells

Metastasis

[124]

miR-375

Serum

PC cells

Metastasis

[124]

miR-290,-378

PC cells

/

Prognosis

[127]

miR-1290

Plasma

/

Prognosis

[124]

Ovarian cancer

miR-21-5p

CP70

A2780

Drug resistance

[128]

miR-127-3p

/

OVCAR-3 and Caov-3 cells

Proliferation

[129]

miR-200a/b/c/141

SKOV-3 and OVCAR-3

Ovarian cancer cells (OC)

Proliferation

[103]

miR-339-5p

OC ES-2 cells

Endothelial cells

Proliferation and metastasis

[129]

miR-409-3p

OC ES-2 cells

Endothelial cells

Proliferation and metastasis

[129]

Breast cancer

miR-16

EGCG-treated 4 T1 cells

Macrophages

Metastasis

[130]

miR-21

Bone marrow-derived MSCs

Breast cancer cells

Proliferation

[131]

miR-23b

Bone marrow mesenchymal stem cells

Breast cancer cells

Dormancy

[132]

miR-105

MDA-MB-231

Endothelial cells

Metastasis

[133]

miR-10b

MDA-MB-231

HMLE (MCF-7)

Metastasis

[134]

miR-122

Breast cancer patients/ MCF10A

Recipient pre-metastatic niche cells

Metastasis

[135]

miR-134

Hs578T and Hs578Ts(i)8

Breast cancer cells

Drug resistance

[30]

miR-200

Metastatic breast cells

Non-metastatic breast cells

Metastasis

[136]

miR-221/ -222

MCF-7 (Tamoxifen resistant)

MCF-7 (Tamoxifen-sensitive)

Drug resistance

[137]

miR-223-3p

IL-4-activated macrophages

MDA-MB-231

Metastasis

[138]

MiR-373

breast cancer cells

/

Malignant prediction

[127]

miR-503

Endothelial cells

Breast cancer cells

Metastasis

[139]

Neuroblastoma

miR-21

NBL cells

Human monocytes

Drug resistance

[124]

Hematological malignancies

miR-21

CLL cells

MSCs and endothelial cells

Metastasis

[140]

miR-92a

K562 cells

Umbilical vein endothelial cells

Metastasis

[18]

miR-126

LAMA84

Endothelial cells

Metastasis

[141]

miR-135b

Multiple myeloma cells

endothelial cells

Metastasis, angiogenesis

[142]

miR-202-3p

Chronic lymphocytic leukemia (MEC1)

Human stromal cells

Proliferation

[143]

miR-210

K562 under hypoxic conditions

Umbilical vein endothelial cells

Metastasis

[144]

Melanoma

miR-31, -185, and -34b

A375 and SK-MEL-28

Normal melanocytes

Metastasis

[145]

Melanoma

miR-125b-5p

PLX4032-resistant melanoma cell line

Primary melanoma cell lines

Metastasis

[146]

miR-222

Metastatic melanoma cell lines

Primary melanoma cell lines

Metastasis

[147]

Merkel Cell Carcinoma (MCC)

miR-30a, miR-34, miR-142-3p, miR-1539

MCV-positive or -negative tumors

/

MCPyV infection

[148]