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Table 1 Exosomal miRNAs as prognostic molecular markers

From: The role of Exosomal miRNAs in cancer

Cancer Exosomal miRNAs Donor Recipient Type of biomarker Refs.
Lung cancer miR-21 Bronchial epithelial (HBE) cells Normal HBE cells Angiogenesis [88]
  miR-23b-3p, miR-10b-5p and miR-21-5p Plasmatic exosomes Non-small cell lung cancer cells(NSCLC) Progression, angiogenesis and metastasis [61, 109]
  miR-210 Lung adenocarcinoma Stromal cells Angiogenesis [110]
  miR-155/-146a Immune cells Immune cells Inflammation [111]
  miR-192 A549 Endothelial cells Bone metastasis [112]
  miR-494 Lung adenocarcinoma cells Lymph nodes, lung cells Pre-metastasis [113]
Esophageal cancer(ESCC) miR-30a ESCC cells / Proliferation [114]
Gastric cancer miR-21 Macrophage BGC-823 Metastasis [115]
  miR-221 Mesenchymal stem cells HGC-27 Metastasis [116]
Colorectal cancer(CRC) miR-19a CRC cells / Metastasis [117]
  miR-21, -192 and-221 HCT-15, SW480 and WiDr HepG2 and A549 / [118]
  miR-23b-3p Blood plasma isolated from CRC patients Colon cancer cells Inhibitor [109]
Liver cancer miR-122 Huh7 cells HepG2 cells Inhibitor [119]
  miR-223 Macrophages Hepatocellular carcinoma cells (HuH7 and HepG2) Inhibitor [120]
Pancreatic cancer miR-19b PCa cells Urine Diagnosis [121]
  miR-23b-3p PANC-1 cells PANC-1 cells Proliferation and metastasis [30, 109]
  miR-122-5p and miR-193b-3p Plasma samples Pancreatic cancer cells Proliferation [122]
  miR-141 PCa cells Serum Metastasis [100]
  miR-141, miR-375 PCa cells Serum Metastasis [98]
  miR-145 Urine PCa cells Suppressor [98]
  miR-196a-5p Urine PCa cells Metastasis [123]
  miR-200c-3p Urine PCa cells Suppressor [98]
  miR-1246 Serum PCa cells Metastasis [103]
  miR-1290, miR-375 PCa cells Plasma Survival prognosis [124]
Bladder cancer Exosome-derived miR- 29c miR-29c BIU-87 cells Apoptosis [125]
Prostate cancer miR-34a Docetaxel-resistant PC cells Docetaxel-resistant Drug resistance [126]
  miR-125a DIAPH3-silenced cells macrophages Proliferation [126]
  miR-141 Bone metastatic PCa cells Bone cells Metastasis [124]
  miR-375 Serum PC cells Metastasis [124]
  miR-290,-378 PC cells / Prognosis [127]
  miR-1290 Plasma / Prognosis [124]
Ovarian cancer miR-21-5p CP70 A2780 Drug resistance [128]
  miR-127-3p / OVCAR-3 and Caov-3 cells Proliferation [129]
  miR-200a/b/c/141 SKOV-3 and OVCAR-3 Ovarian cancer cells (OC) Proliferation [103]
  miR-339-5p OC ES-2 cells Endothelial cells Proliferation and metastasis [129]
  miR-409-3p OC ES-2 cells Endothelial cells Proliferation and metastasis [129]
Breast cancer miR-16 EGCG-treated 4 T1 cells Macrophages Metastasis [130]
  miR-21 Bone marrow-derived MSCs Breast cancer cells Proliferation [131]
  miR-23b Bone marrow mesenchymal stem cells Breast cancer cells Dormancy [132]
  miR-105 MDA-MB-231 Endothelial cells Metastasis [133]
  miR-10b MDA-MB-231 HMLE (MCF-7) Metastasis [134]
  miR-122 Breast cancer patients/ MCF10A Recipient pre-metastatic niche cells Metastasis [135]
  miR-134 Hs578T and Hs578Ts(i)8 Breast cancer cells Drug resistance [30]
  miR-200 Metastatic breast cells Non-metastatic breast cells Metastasis [136]
  miR-221/ -222 MCF-7 (Tamoxifen resistant) MCF-7 (Tamoxifen-sensitive) Drug resistance [137]
  miR-223-3p IL-4-activated macrophages MDA-MB-231 Metastasis [138]
  MiR-373 breast cancer cells / Malignant prediction [127]
  miR-503 Endothelial cells Breast cancer cells Metastasis [139]
Neuroblastoma miR-21 NBL cells Human monocytes Drug resistance [124]
Hematological malignancies miR-21 CLL cells MSCs and endothelial cells Metastasis [140]
  miR-92a K562 cells Umbilical vein endothelial cells Metastasis [18]
  miR-126 LAMA84 Endothelial cells Metastasis [141]
  miR-135b Multiple myeloma cells endothelial cells Metastasis, angiogenesis [142]
  miR-202-3p Chronic lymphocytic leukemia (MEC1) Human stromal cells Proliferation [143]
  miR-210 K562 under hypoxic conditions Umbilical vein endothelial cells Metastasis [144]
Melanoma miR-31, -185, and -34b A375 and SK-MEL-28 Normal melanocytes Metastasis [145]
Melanoma miR-125b-5p PLX4032-resistant melanoma cell line Primary melanoma cell lines Metastasis [146]
  miR-222 Metastatic melanoma cell lines Primary melanoma cell lines Metastasis [147]
Merkel Cell Carcinoma (MCC) miR-30a, miR-34, miR-142-3p, miR-1539 MCV-positive or -negative tumors / MCPyV infection [148]