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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages

Fig. 4

GM-CSF treatment leads to decreased erythroblasts and EBI formation in mouse BM. A Plot of CD71 versus c-Kit of DAPI−Linages−CD16−CD32−CD41−CD34−Sca1−cells in control and GM-CSF-treated mice BM (I: BFU-E, II: BFU-E/CFU-E mixture and III: CFU-E). B Quantitative analyses of BFU-E and CFU-E numbers in control and GM-CSF-treated mice BM. C Representative plot of CD44 versus FSC of Ter119+cells revealing various staged erythroid cells in control and GM-CSF-treated mice BM. D Quantitative analysis of erythroblasts. E Representative cytospin images of EBI enrichment in control and GM-CSF treated mice BM. F Quantitative analysis of EBI numbers in one slide. G Quantitative analysis of erythroblasts surrounded with macrophages. *P < 0.05, ** P < 0.01 *** P < 0.001. N = 6

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