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Table 2 The sensitivity analyses of the associations of the trajectory groups with CVDs and all-cause mortalitya

From: Moderate physical activity may not decrease the risk of cardiovascular disease in persistently overweight and obesity adults

 

Sensitivity 1b

P

Sensitivity 2c

P

Sensitivity 3d

P

SHR (95% CI)

HR (95% CI)

SHR (95% CI)

CVDse

      

 Persistent NW with MPA (reference)

–

–

–

–

  

 Rising to OW in NW status with MPA

0.97 (0.85–1.11)

0.6513

0.91 (0.80–1.04)

0.1637

0.94 (0.83–1.08)

0.3795

 Persistent OW with MPA

1.33 (1.24–1.44)

 < 0.0001

1.33 (1.23–1.43)

 < 0.0001

1.35 (1.26–1.46)

 < 0.0001

 Decline to NW in OW status with MPA

1.03 (0.91–1.16)

0.6518

0.97 (0.86–1.09)

0.6068

1.03 (0.91–1.16)

0.6729

 Decline to OW in obesity status with MPA

1.24 (1.08–1.42)

0.0024

1.16 (1.01–1.33)

0.0313

1.24 (1.08–1.42)

0.0021

 Persistent obesity with MPA

1.55 (1.42–1.70)

 < 0.0001

1.58 (1.44–1.73)

 < 0.0001

1.60 (1.46–1.75)

 < 0.0001

MI

      

 Persistent NW with MPA (reference)

–

–

–

–

  

 Rising to OW in NW status with MPA

0.70 (0.49–1.00)

0.0524

0.69 (0.48–0.98)

0.0357

0.71 (0.50–1.01)

0.0556

 Persistent OW with MPA

1.29 (1.08–1.54)

0.0045

1.29 (1.08–1.53)

0.0046

1.31 (1.10–1.56)

0.0024

 Decline to NW in OW status with MPA

0.85 (0.62–1.16)

0.2915

0.81 (0.59–1.10)

0.1676

0.85 (0.63–1.16)

0.3064

 Decline to OW in obesity status with MPA

1.13 (0.81–1.58)

0.4580

1.06 (0.76–1.48)

0.7223

1.13 (0.81–1.58)

0.4619

 Persistent obesity with MPA

1.54 (1.25–1.91)

 < 0.0001

1.59 (1.29–1.96)

 < 0.0001

1.61 (1.30–1.98)

 < 0.0001

Stroke

      

 Persistent NW with MPA (reference)

–

–

–

–

  

 Rising to OW in NW status with MPA

1.02 (0.89–1.18)

0.7796

0.95 (0.83–1.10)

0.4892

0.99 (0.86–1.14)

0.8361

 Persistent OW with MPA

1.34 (1.23–1.45)

 < 0.0001

1.33 (1.23–1.44)

 < 0.0001

1.36 (1.25–1.47)

 < 0.0001

 Decline to NW in OW status with MPA

1.07 (0.94–1.22)

0.3185

1.01 (0.88–1.15)

0.9416

1.07 (0.94–1.21)

0.3402

 Decline to OW in obesity status with MPA

1.26 (1.09–1.47)

0.0023

1.19 (1.02–1.38)

0.0234

1.27 (1.09–1.47)

0.0017

 Persistent obesity with MPA

1.55 (1.40–1.72)

 < 0.0001

1.57 (1.43–1.73)

 < 0.0001

1.59 (1.44–1.76)

 < 0.0001

All-cause mortality

      

 Persistent NW with MPA (reference)

–

–

–

–

  

 Rising to OW with MPA in NW status with APA

–

–

0.74 (0.67–0.81)

 < 0.0001

–

–

 Persistent OW with MPA

–

–

0.93 (0.88–0.98)

0.0036

–

–

 Decline to NW in OW status with MPA

–

–

0.75 (0.69–0.82)

 < 0.0001

–

–

 Persistent obesity with MPA

–

–

1.02 (0.95–1.08)

0.6192

–

–

  1. aMultivariate cox regression analysis was used to evaluate the association of CVDs and all-cause mortality risk with trajectory groups, adjusting for potential confounding factors. HR calculated by cox regression adjusting age, sex, type of work, seat time, walking instead of the elevators, educational level, smoking status, drinking status, family per-member monthly income, salt intake, drinking tea status, CRP, and history of diseases (hypertension, diabetes, and hyperlipidemia)
  2. bConsidering non-CVD events death as a competing risk event rather than a censoring event, the association of all-cause mortality risk with trajectory groups was evaluated using competing risk model
  3. cThe association of all-cause mortality risk with trajectory groups was evaluated using time-depending model. Age, type of work, seat time, walking instead of the elevators, smoking status, drinking status, family per-member monthly income, salt intake, drinking tea status, CRP, and history of diseases (hypertension, diabetes, and hyperlipidemia) were updated during 2006–2016. Sex and educational level were time-invariant variables
  4. dThe association of all-cause mortality risk with trajectory groups was evaluated using time-depending competing risk model
  5. eCVDs included MI and stroke (cerebral infarction, cerebral hemorrhages, and subarachnoid hemorrhage)
  6. APA active physical activity, CI confidence interval, CRP c-reaction protein, CVD cardiovascular disease, HR hazard ratio, MI myocardial infarction, MPA moderate physical activity, NW normal-weight, OW overweight, SHR sub-distribution hazard ratio
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Journal of Translational Medicine

ISSN: 1479-5876

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