Table 3 The ontology of predicted target genes
From: From GWAS to drug screening: repurposing antipsychotics for glioblastoma
Predicted targets | Norcyclobenzaprine | |||
|---|---|---|---|---|
GO biological process complete | Over/under | Fold enrichment | FDR | |
PARP1 PARP2 ORM2 RBP1 SETD7 ESRRG PGR ESR1 NCOA2 RARB | Positive regulation of RNA biosynthetic process (GO:1902680) |  +  | 7.78 | 3.68 E−03 |
Positive regulation of transcription DNA-templated (GO:0045893) |  +  | 7.78 | 4.39 E−03 | |
Positive regulation of RNA metabolic process (GO:0051254) |  +  | 7.15 | 4.66 E−03 | |
Positive regulation of macromolecule biosynthetic process (GO:0010557) |  +  | 6.8 | 4.69 E−03 | |
Transcription initiation from RNA polymerase II promoter (GO:0006367) |  +  | 41.69 | 4.84 E−03 | |
Positive regulation of macromolecule metabolic process (GO:0010604) |  +  | 4.5 | 4.92 E−03 | |
Positive regulation of transcription by RNA polymerase II (GO:0045944) |  +  | 9.15 | 4.93 E−03 | |
Response to steroid hormone (GO:0048545) |  +  | 27.79 | 4.94 E−03 | |
Intracellular receptor signaling pathway (GO:0030522) |  +  | 32 | 4.97 E−03 | |
Positive regulation of biosynthetic process (GO:0009891) |  +  | 6.32 | 5.03 E−03 | |
Epithelial cell development (GO:0002064) |  +  | 31.37 | 5.11 E−03 | |
transcription by RNA polymerase II (GO:0006366) |  +  | 20.74 | 5.11 E−03 | |
positive regulation of cellular biosynthetic process (GO:0031328) |  +  | 6.44 | 5.14 E−03 | |
DNA-templated transcription initiation (GO:0006352) |  +  | 32.5 | 5.24 E−03 | |
DNA ADP-ribosylation (GO:0030592) |  +  |  > 100 | 5.27 E−03 | |
Peptidyl-serine ADP-ribosylation (GO:0018312) |  +  |  > 100 | 5.44 E−03 | |
Positive regulation of nucleic acid-templated transcription (GO:1903508) |  +  | 7.78 | 5.49 E−03 | |
Response to hormone (GO:0009725) |  +  | 11.61 | 5.74 E−03 | |
Positive regulation of metabolic process (GO:0009893) |  +  | 4.15 | 5.76 E−03 | |
Positive regulation of nucleobase-containing compound metabolic process (GO:0045935) |  +  | 6.53 | 5.93 E−03 | |
Hormone-mediated signaling pathway (GO:0009755) |  +  | 48.37 | 6.34 E−03 | |
Cellular response to hormone stimulus (GO:0032870) |  +  | 17.97 | 6.92 E−03 | |
Mammary gland branching involved in pregnancy (GO:0060745) |  +  |  > 100 | 7.72 E−03 | |
RNA biosynthetic process (GO:0032774) |  +  | 14.59 | 7.95 E−03 | |
Retinoic acid biosynthetic process (GO:0002138) |  +  |  > 100 | 8.02 E−03 | |
Steroid hormone mediated signaling pathway (GO:0043401) |  +  | 66.01 | 8.16 E−03 | |
Nucleic acid-templated transcription (GO:0097659) |  +  | 14.92 | 8.33 E−03 | |
Transcription, DNA-templated (GO:0006351) |  +  | 14.95 | 8.61 E−03 | |
Diterpenoid biosynthetic process (GO:0016102) |  +  |  > 100 | 8.69 E−03 | |
Positive regulation of nitrogen compound metabolic process (GO:0051173) |  +  | 4.57 | 8.70 E−03 | |
Protein poly-ADP-ribosylation (GO:0070212) |  +  |  > 100 | 8.98 E−03 | |
Vitamin A metabolic process (GO:0006776) |  +  |  > 100 | 9.95 E−03 | |
Predicted targets | Protriptyline | |||
|---|---|---|---|---|
GO biological process complete | Over/under | Fold enrichment | FDR | |
RBP1 PGR NCOA2 PARP2 PARP1 RXRA RARB CHKA RARG ORM2 | Cellular response to hormone stimulus (GO:0032870) |  +  | 17.97 | 3.46 E−03 |
Retinoic acid receptor signaling pathway (GO:0048384) |  +  |  > 100 | 4.74 E−03 | |
Hormone-mediated signaling pathway (GO:0009755) |  +  | 48.37 | 6.34 E−03 | |
Transcription by RNA polymerase II (GO:0006366) |  +  | 20.74 | 8.18 E−03 | |
Positive regulation of transcription by RNA polymerase II (GO:0045944) |  +  | 9.15 | 8.21 E−03 | |
DNA ADP-ribosylation (GO:0030592) |  +  |  > 100 | 8.29 E−03 | |
Transcription initiation from RNA polymerase II promoter (GO:0006367) |  +  | 41.69 | 8.47 E−03 | |
Epithelial cell development (GO:0002064) |  +  | 31.37 | 8.51 E−03 | |
Intracellular receptor signaling pathway (GO:0030522) |  +  | 32 | 8.59 E−03 | |
DNA-templated transcription, initiation (GO:0006352) |  +  | 32.5 | 8.91 E−03 | |
Peptidyl-serine ADP-ribosylation (GO:0018312) |  +  |  > 100 | 9.66 E−03 | |