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Table 2 Univariate and multivariate cox proportional hazard model for disease free survival (DFS) and overall survival (OS) in TNBC patients

From: CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1

Variables

Univariate analysis

Multivariate analysis

DFS

OS

DFS

OS

HR (95% CI)

P a

HR (95% CI)

P a

HR (95% CI)

P a

HR (95% CI)

P a

Age (years)

 

 ≤ 50

Reference

 

Reference

     

 > 50

0.65 (0.38–1.11)

0.114

0.95 (0.50–1.81)

0.870

    

Tumor size

 

 ≤ 2 cm

Reference

 

Reference

 

Reference

   

 > 2 cm

1.96 (1.10–3.50)

0.023

1.82 (0.90–3.67)

0.098

1.71 (0.95–3.07)

0.073

  

Lymph nodes metastasis

 

 No

Reference

 

Reference

 

Reference

 

Reference

 

 Yes

1.82 (1.08–3.07)

0.026

2.00 (1.05–3.84)

0.036

1.65 (0.97–2.79)

0.065

1.85 (0.96–3.55)

0.066

Grade

 

 I + II

Reference

 

Reference

     

 III

1.50 (0.85–2.65)

0.164

1.75 (0.85–3.62)

0.130

    

Lymphovascular invasion

     

 No

Reference

 

Reference

     

 Yes

1.66 (0.98–2.81)

0.057

1.47 (0.77–2.81)

0.240

    

CTPS1 expression

 

 Low

Reference

 

Reference

 

Reference

 

Reference

 

 High

1.97 (1.10–3.55)

0.010

2.49 (1.20–5.15)

0.014

1.90 (1.07–3.37)

0.029

2.34 (1.13–4.84)

0.023

  1. HR hazard ratio, CI confidence interval, DFS disease free survival, OS overall survival
  2. aThe P value was adjusted by the univariate Cox proportional hazard regression model
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Journal of Translational Medicine

ISSN: 1479-5876

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