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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1

Fig. 2

Knockdown of CTPS1 suppresses cell proliferation, migration, invasion and induces apoptosis of TNBC cells in vitro. a CTPS1 protein expression in TNBC cell lines was analyzed by western blot. b The knockdown efficiency of shCTPS1 was detected by qRT-PCR in MDA-MB-231 and HCC1937 cells. c The knockdown efficiency of shCTPS1 for following experiments was validated by western blot. d, e Cell proliferation was detected by CCK8 and colony formation assay following CTPS1 knockdown in TNBC cells. f Cell migration and invasion ability was determined by transwell assay following CTPS1 knockdown in TNBC cells. g Cell apoptosis of TNBC cells following CTPS1 knockdown was analyzed by flow cytometer. All data are presented as the mean ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001

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