Mendelian randomization study updates the effect of 25-hydroxyvitamin D levels on the risk of multiple sclerosis

Table 5 The causal association of serum 25OHD levels with MS

Method	nsnp	Beta	SE	p val	OR	OR_lci95	OR_uci95
MR Egger	20	− 0.940	0.251	0.001	0.391	0.239	0.639
Weighted median	20	− 0.835	0.162	0.000	0.434	0.316	0.596
IVW	20	− 0.781	0.165	0.000	0.458	0.331	0.633
Simple mode	20	− 1.484	0.560	0.016	0.227	0.076	0.679
Weighted mode	20	− 0.913	0.165	0.000	0.401	0.290	0.554

IVW Inverse variance weighted. IVW was based on multiplicative random effects. nsnp the number of single-nucleotide polymorphism. Beta: the regression coefficient based on 25OHD raising effect allele. SE: standard error. p < 0.05 represents the causal association of serum 25OHD levels with MS. OR Odds ratio. OR_lci95 Lower limit of 95% confidence interval for OR. OR_uci95 Upper limit of 95% confidence interval for OR

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