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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy

Fig. 3

NQO1 overexpression reduced renal cell apoptosis. A–C The expression of Bax, Bcl-2, and Cleaved Caspase-3 was measured by western blotting (n = 6). D Immunohistochemical staining of Bax, Bcl-2, and Cleaved Caspase-3 in kidney sections (scale bar, 50 μm, n = 9). D Apoptosis was determined using the TUNEL assay, and D the mean apoptotic cells per field was determined (magnification, × 400, n = 9). Values are expressed as the mean ± SD. **P < 0.01 versus the db/m group; ##P < 0.01 versus the db/db + AAV-Control group

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