Fig. 2

NQO1 overexpression suppresses oxidative stress in diabetic kidneys. A The protein expression of Nox1 and Nox4 was evaluated by western blotting (n = 6). B–E Immunohistochemical staining analysis of Nox1, Nox4 and 8-OHdG expression in the renal tissues of mice (scale bar, 50 μm, n = 9). 8-OHdG: 8-Hydroxy-2'-deoxyguanosine. Values are expressed as the mean ± SD. **P < 0.01 versus the db/m group; ^##P < 0.01 versus the db/db + AAV-Control group