Fig. 2
From: TRPC3, but not TRPC1, as a good therapeutic target for standalone or complementary treatment of DMD
Evolution of resting calcium homeostasis in EDL muscle fibers from WT and DMDmdx rats during post-natal development. A Resting cytosolic calcium concentration ([Ca2+]c) B Resting sarcolemmal permeability to calcium (SPCa). [Ca2+]c and SPCa were measured in Fura2 loaded single fibers from mechanically isolated bundles of EDL muscles in WT and DMDmdx rats of 1.5 to 7.0 months of age. SPCa was measured using the manganese quenching of Fura2 technique. Each bar corresponds to mean value ± SEM measured in n single fibers from N animals (n/N are indicated at the bottom the bars). *: significantly different from mean value measured in age-matched WT animals. $: significantly different from mean value measured in animals from the same genotype of 1.5 months of age. P < 0.05, Two-way ANOVA and Fisher-LSD post-hoc test for pairwise comparisons