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Table 1 Definitions of AJCC TNM System

From: A novel staging system and clinical predictive nomogram for more accurate staging and prognosis of malignant pancreatic intraductal papillary mucinous neoplasms: a population-based study

TNM 7th TNM 8th
Tis carcinoma in situ Tis carcinoma in situ
T1 tumor limited to the pancreas, 2 cm or less in greatest dimension T1 tumor ≤ 2 cm in greatest dimension
T2 tumor limited to the pancreas, more than 2 cm in greatest dimension T2 tumor > 2 cm and ≤ 4 cm in greatest dimension
T3 tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery T3 tumor > 4 cm in greatest dimension
T4 tumor involves the celiac axis or the superior mesenteric artery (unresectable primary tumor) T4 tumor involves celiac axis, superior mesenteric artery, and/or common hepatic artery, regardless of size
N0 to regional lymph node metastasis N0 to regional lymph node metastases
N1 regional lymph node metastasis N1 metastasis in one to three regional lymph nodes
  N2 metastasis in four or more regional lymph nodes
M0 no distant metastasis M0 mo distant metastasis
M1 distant metastasis M1 distant metastasis
AJCC 7th AJCC 8th AJCC modified
Stage 0 Tis N0 M0 Stage 0 Tis N0 M0 Stage 0 Tis N0 M0
Stage IA T1 N0 M0 Stage IA T1 N0 M0 Stage IA T1 N0 M0
Stage IB T2 N0 M0 Stage IB T2 N0 M0 Stage IB T2–3 N0 M0
Stage IIA T3 N0 M0 Stage IIA T3 N0 M0 Stage IIA T1–3 N1 M0
Stage IIB T1-3 N1 M0 Stage IIB T1-3 N1 M0 Stage IIB T1-3 N2 M0
Stage III T4 Nany M0 Stage III Tany N2 M0, T4 Nany M0 Stage III T4 Nany M0
Stage IV Tany Nany M1 Stage IV Tany Nany M1 Stage IV Tany Nany M1