Skip to main content
Fig. 6 | Journal of Translational Medicine

Fig. 6

From: VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy

Fig. 6

Analysis of aged VCPR155H/+ mice with CB-5083 treatment. VCPR155H/+ mice were treated with CB-5083 for 6 months starting from 12 months of age. A Muscle lysates were generated from VCPR155H/+ mice treated with and without CB-5083 (n = 3 per group) and subjected to immunoblotting using anti-VCP, MFN2, p62, TDP-43, TFEB, and LC3I/II antibodies. GAPDH was used as a loading control. B Quantification of Western blot analysis shown in (A). A trend of diminution of biomarker expression was observed for VCPR155H/+ mice treated with CB-5083, especially in p62, TFEB, and LC3I/II. Western blot was repeated three times. Statistical analysis was performed by one-way ANOVA followed by Fisher’s LSD test

Back to article page