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Table 4 Multivariate COX regression analysis of overall survival

From: Cancer-associated fibroblasts promote oral squamous cell carcinoma progression through LOX-mediated matrix stiffness

Variables

P-value

Risk ratio

95% CI

Sex (male, female)

0.841

1.117

(0.378, 3.299)

Age (≤ 50, > 50)

0.795

0.995

(0.954, 1.037)

Tumor location (tongue, gingiva, buccal mucosa, palate, lower lip, jaw, others)

0.906

1.02

(0.737, 1.41)

Tumor size (T1–T4)

0.656

1.231

(0.492, 3.081)

Lymph node metastasiss

0.894

1.089

(0.309, 3.845)

Clinical stage (I, II, III, IV)

0.762

0.834

(0.256, 2.712)

Pathological grade

0.516

0.72

(0.267, 1.94)

Local infiltration

0.676

1.313

(0.367, 4.702)

α-SMA in tumor stroma (low, high)

0.62

0.735

(0.217, 2.487)

LOX in tumor stroma ( low, high)

0.017

13.062

(1.58, 107.992)

  1. CI confidence interval
  2. Bold values signify P-value < 0.05