Fig. 3

LOX expressed by CAFs affects ECM remodeling in vitro. A NFs and CAFs were co-cultured with collagen gels and the contraction of collagen gels was assessed photographically at 0 h and 72 h. Collagen gels diameter was measured every day. B The diameter of collagen in each group was statistically analyzed. C Representative microscope images of collagen co-cultured with NFs and CAFs were taken by SEM. D Quantitative analysis of collagen pore size was calculated by ImageJ. E Relative stiffness of collagen were measured by MARS60 microinfrared rheometer. Data was representative of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001