Fig. 1

LOX expressed in tumor stroma is colocalized with CAFs. A Distribution of LOX expression was detected by multiple IHC staining. Representative images at 100 × magnification. FAP (green), EPCAM (red), LOX (cyan), DAPI (blue). B Colocalization of LOX and CAFs in the stroma were shown. Representative images of high and low expression levels of FAP, α-SMA and LOX in tumor stroma at 100 × magnification. FAP (green), α-SMA (red), LOX (cyan), DAPI (blue). C The Kaplan–Meier survival curves of prognostic models based on LOX expression in tumor stroma for patients with OSCC