From: Detecting prognostic biomarkers of breast cancer by regularized Cox proportional hazards models
Characteristics | Datasets | |||||||
---|---|---|---|---|---|---|---|---|
Discovery | External validation (totally 1848 patients) | |||||||
Cohort | TCGA | GSE1456 | GSE2034 | GSE7390 | GSE17705 | GSE21653 | GSE35629 | |
Platform | DCC | GPL96 | GPL96 | GPL96 | GPL570 | GPL570 | GPL1390 | |
Survival | OS | OS, DMFS | DMFS | OS, DFS, TDM | RFS | DFS | OS, RFS | |
# of samples | 1080 | 159, 159 | 286 | 198, 198, 198 | 298 | 248 | 53, 51 | |
# of genes | 20220 | 13701 | 13701 | 13701 | 13701 | 21835 | 7800 | |
Age | \(\le 60\) | 587 | Â | Â | 195 | Â | 157 | Â |
\(>60\) | 479 | Â | Â | 3 | Â | 91 | Â | |
NA | 14 | Â | Â | 0 | Â | 0 | Â | |
Average | 58 | Â | Â | 46 | Â | 55 | Â | |
IQR | (49, 67) | Â | Â | (42, 51) | Â | (45, 66) | Â | |
Tumor size (mm) | Â | Â | Â | 21.81 | Â | Â | Â | |
Stage | I | 181 | 28 | Â | 30 | Â | 43 | Â |
II | 611 | 58 | Â | 83 | Â | 84 | Â | |
III | 246 | 61 | Â | 83 | Â | 121 | Â | |
IV | 20 | Â | Â | 0 | Â | 0 | Â | |
V | 14 | Â | Â | 0 | Â | 0 | Â | |
NA | 8 | 12 | Â | 2 | Â | 4 | Â | |
T stage | T1 | 279 | Â | Â | Â | Â | 57 | Â |
T2 | 626 | Â | Â | Â | Â | 121 | Â | |
T3 | 134 | Â | Â | Â | Â | 63 | Â | |
T4 | 38 | Â | Â | Â | Â | 0 | Â | |
NX | 3 | Â | Â | Â | Â | 7 | Â | |
N stage | N0 | 505 | Â | Â | Â | Â | Â | Â |
N1 | 359 | Â | Â | Â | Â | Â | Â | |
N2 | 120 | Â | Â | Â | Â | Â | Â | |
N3 | 76 | Â | Â | Â | Â | Â | Â | |
NX | 20 | Â | Â | Â | Â | Â | Â | |
M stage | M0 | 896 | Â | Â | Â | Â | Â | Â |
M1 | 22 | Â | Â | Â | Â | Â | Â | |
MX | 162 | Â | Â | Â | Â | Â | Â | |
Status | 0 | 928 | 130, 119 | 276 | 142, 107, 147 | 227 | 169 | 29, 30 |
1 | 152 | 29, 40 | 10 | 56, 91, 51 | 71 | 79 | 24, 21 | |
References | [61] | [62] | [63] | [64] | [65] | [66] | [67] |