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Table 1 The basic information and clinical characteristics of patients with BRCA patients

From: Detecting prognostic biomarkers of breast cancer by regularized Cox proportional hazards models

Characteristics Datasets
Discovery External validation (totally 1848 patients)
Cohort TCGA GSE1456 GSE2034 GSE7390 GSE17705 GSE21653 GSE35629
Platform DCC GPL96 GPL96 GPL96 GPL570 GPL570 GPL1390
Survival OS OS, DMFS DMFS OS, DFS, TDM RFS DFS OS, RFS
# of samples 1080 159, 159 286 198, 198, 198 298 248 53, 51
# of genes 20220 13701 13701 13701 13701 21835 7800
Age \(\le 60\) 587    195   157  
\(>60\) 479    3   91  
NA 14    0   0  
Average 58    46   55  
IQR (49, 67)    (42, 51)   (45, 66)  
Tumor size (mm)     21.81    
Stage I 181 28   30   43  
II 611 58   83   84  
III 246 61   83   121  
IV 20    0   0  
V 14    0   0  
NA 8 12   2   4  
T stage T1 279      57  
T2 626      121  
T3 134      63  
T4 38      0  
NX 3      7  
N stage N0 505       
N1 359       
N2 120       
N3 76       
NX 20       
M stage M0 896       
M1 22       
MX 162       
Status 0 928 130, 119 276 142, 107, 147 227 169 29, 30
1 152 29, 40 10 56, 91, 51 71 79 24, 21
References [61] [62] [63] [64] [65] [66] [67]
  1. *IQR: Interquartile range (1, 3). OS overall survival, DMFS distant metastasis-free survival, TDM time to distant metastasis, DFS disease-free survival, RFS relapse free survival. For OS: 1 = dead from BRCA, 0 = alive or censored. For DMFS: 1 = relapse, 0 = no relapse or censored. For TDM, DFS and RFS: 1 = event, 0 = censoring