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Table 1 The basic information and clinical characteristics of patients with BRCA patients

From: Detecting prognostic biomarkers of breast cancer by regularized Cox proportional hazards models

Characteristics

Datasets

Discovery

External validation (totally 1848 patients)

Cohort

TCGA

GSE1456

GSE2034

GSE7390

GSE17705

GSE21653

GSE35629

Platform

DCC

GPL96

GPL96

GPL96

GPL570

GPL570

GPL1390

Survival

OS

OS, DMFS

DMFS

OS, DFS, TDM

RFS

DFS

OS, RFS

# of samples

1080

159, 159

286

198, 198, 198

298

248

53, 51

# of genes

20220

13701

13701

13701

13701

21835

7800

Age

\(\le 60\)

587

  

195

 

157

 

\(>60\)

479

  

3

 

91

 

NA

14

  

0

 

0

 

Average

58

  

46

 

55

 

IQR

(49, 67)

  

(42, 51)

 

(45, 66)

 

Tumor size (mm)

   

21.81

   

Stage

I

181

28

 

30

 

43

 

II

611

58

 

83

 

84

 

III

246

61

 

83

 

121

 

IV

20

  

0

 

0

 

V

14

  

0

 

0

 

NA

8

12

 

2

 

4

 

T stage

T1

279

    

57

 

T2

626

    

121

 

T3

134

    

63

 

T4

38

    

0

 

NX

3

    

7

 

N stage

N0

505

      

N1

359

      

N2

120

      

N3

76

      

NX

20

      

M stage

M0

896

      

M1

22

      

MX

162

      

Status

0

928

130, 119

276

142, 107, 147

227

169

29, 30

1

152

29, 40

10

56, 91, 51

71

79

24, 21

References

[61]

[62]

[63]

[64]

[65]

[66]

[67]

  1. *IQR: Interquartile range (1, 3). OS overall survival, DMFS distant metastasis-free survival, TDM time to distant metastasis, DFS disease-free survival, RFS relapse free survival. For OS: 1 = dead from BRCA, 0 = alive or censored. For DMFS: 1 = relapse, 0 = no relapse or censored. For TDM, DFS and RFS: 1 = event, 0 = censoring