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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Identifying and characterizing lincRNA genomic clusters reveals its cooperative functions in human cancer

Fig. 1

The Global landscape of lincRNA genomic clusters in human cancers. (A) Global map of lincRNA expression, co-expression of lincRNA genomic clusters across cancer types and conservation of lincRNAs. The gray lines in the outermost layer of the map represent lincRNA genomic clusters on each chromosome. The outer layer corresponds to the chromosome map of the human genome; black and white bars represent chromosomal cytobands and red bars represent centromeres. The dots in the map represent co-expression of lincRNA genomic cluster and positions of dots signify in 20 cancer types (BLCA, BRCA, CESC, THCA, GBM, SKCM, KICH, KIRC, KIRP, LGG, LIHC, LUAD, LUSC, OV, STAD, PRAD, HNSC, COAD, UCEC, READ). Line chart in the inner circles of the map represents the conservation of all lincRNA. The heatmap in the inner circles represents average expression levels of tumor samples of each expressed lincRNA in 20 cancer types (BLCA, BRCA, CESC, THCA, GBM, SKCM, KICH, KIRC, KIRP, LGG, LIHC, LUAD, LUSC, OV, STAD, PRAD, HNSC, COAD, UCEC, READ), only expressed lincRNAs (lincRNA expression is greater than 0.1 in more than two samples) were kept. (B) Ideogram showing the cluster size (the number of lincRNAs contained in the clusters) distribution on chromosomes. (C) Six examples of clusters containing cancer-related lincRNA genes are shown

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