Association between pulse pressure, systolic blood pressure and the risk of rapid decline of kidney function among general population without hypertension: results from the China health and retirement longitudinal study (CHARLS)

Table 2 Comparison of kidney function among BP categories

Kidney Function	Overall	PP category		P value	SBP category			P value	DBP category			P value
Kidney Function	Overall	Normal < 60 mmHg	High ≥ 60 mmHg	P value	Low < 120 mmHg	Medium 120–129 mmHg	High 130–139 mmHg	P value	Low < 60 mmHg	Medium 60–74 mmHg	High 75–89 mmHg	P value
eGFR in 2011 (ml/min/1.73m², mean ± SD)	96.4 ± 15.6	97.0 ± 15.3	91.0 ± 16.6	< 0.001	97.6 ± 14.9	96.0 ± 16.3	93.8 ± 16.0	< 0.001	95.5 ± 14.8	96.3 ± 15.7	96.8 ± 15.6	0.261
eGFR in 2015 (ml/min/1.73m², mean ± SD)	91.4 ± 17.2	92.2 ± 16.9	84.8 ± 18.8	< 0.001	92.3 ± 17.0	91.5 ± 17.2	88.9 ± 17.8	< 0.001	89.3 ± 18.7	91.0 ± 17.3	92.9 ± 16.6	< 0.001
Annual decline of eGFR (ml/min/1.73m², IQR)	− 0.9 (− 2.8, 0.6)	− 0.9 (− 2.7, 0.6)	− 1.1 (− 3.2, 0.3)	0.013	− 0.9(− 2.9, 0.5)	− 0.9(− 2.5, 0.6)	− 1.0(− 2.9, 0.8)	0.500	− 1.0(− 2.9, 0.5)	− 1.0(2.9, 0.5)	− 0.8(− 2.5, 0.9)	0.011
Rapid decline of eGFR* (n, %)				0.011				0.141				0.236
No	3839(84.7)	3454(85.1)	385(80.7)		2025(84.5)	1024(86.3)	790(83.3)		444(83.6)	2105(84.1)	1290(85.9)
Yes	695(15.3)	603(14.9)	92(19.3)		373(15.6)	163(13.7)	159(16.8)		87(16.4)	397(15.9)	211(14.1)

BP blood pressure, PP pulse pressure, SBP systolic blood pressure, DBP diastolic blood pressure, eGFR estimated glomerular filtration, SD standard deviation, IQR interquartile range
^*Rapid decline of eGFR was defined as eGFR decline ≥ 4 ml/min/1.73m²/year

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