Fig. 2

TRIM38 expressed lowly in BLCA and down-regulated TRIM38 correlated with advanced clinical characteristics and poor prognosis. a Representative immunohistochemistry (IHC) graphs showing the staining levels of TRIM38 in patients with different tumor grades. scale bars = 100 μm (upper), scale bars = 20 μm (lower). b The results from qRT-PCR analysis exhibited that the TRIM38 mRNA levels were notably upregulated in BLCA samples relative to their adjacent normal tissues. β-actin was detected as the loading control. c–f Low TRIM38 expression levels correlated with tumor metastatic stages, lymph node metastasis, clinical pathological stages and TP53 mutation status. g, h Other BLCA datasets (GSE13507 and GSE32548) were utilized to suggest that patients with low TRIM38 expressions suffered from shorter overall survival (OS) probability compared with patients with high TRIM38