Fig. 1

High-throughput sequencing screens and experimental validations highlighted that TRIM38 was a tumor suppressor in BLCA. a Schematic diagram showing the screening process of prognostic UPS-signature in BLCA. b Gene ontology (GO) analysis revealed the enriched crosstalk based on the prognostic UPS-signature. c Forest plot illustrating the hazard and favorable targets in BLCA, where red genes represented the risk factors and green genes represented the protective factors. d Correlation heatmap showing the selected 10 genes in BLCA, where blueness exhibited the positive associations and brownness showed the negative relationships. e MTT assays validated the functional roles of indicated 10 genes via transfection with individual siRNAs, respectively. f Kaplan–Meier analysis indicated that BLCA patients with low TRIM38 levels had a higher risk of tumor progression relative to those with high TRIM38 expressions, as indicated by the log-rank test