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Table 3 Cox Regression Models in predicting cardiovascular outcomes according to physical signs

From: Relations of physical signs to genotype, lipid and inflammatory markers, coronary stenosis or calcification, and outcomes in patients with heterozygous familial hypercholesterolemia

CVEs Events, n/total Hazard ratio (95% CI)
Crude model Adjusted model
Non-TX/CA 24/200 1 (reference) 1 (reference)
TX/CA 11/50 2.86 (1.37–5.98)** 2.75 (1.04–7.26)*
Group1 TX/CA (−) Mu (−) 12/108 1 (reference) 1 (reference)
Group2 TX/CA (−) Mu (+) 12/92 1.07 (0.48–2.39) 0.82 (0.34–1.98)
Group3 TX/CA (+) Mu (−) 1/14 1.01 (0.13–7.89) 1.02 (0.12–8.49)
Group4 TX/CA (+) Mu (+) 10/36 3.66 (1.55–8.64)** 3.34 (1.04–10.72)*
  1. Adjusted model was adjusted for age, sex, BMI, CAD, smoking, hypertension, DM, family history of CAD, adjusted LDL-C levels, lipid-lowering therapy, LDL cholesterol year score and total cholesterol year score
  2. TX: tendon xanthomas; CA: corneal arcus; Mu: mutation; Mu (+), mutation positive; Mu (−), mutation negative
  3. *p < 0.05, **p < 0.01