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Table 3 Cox Regression Models in predicting cardiovascular outcomes according to physical signs

From: Relations of physical signs to genotype, lipid and inflammatory markers, coronary stenosis or calcification, and outcomes in patients with heterozygous familial hypercholesterolemia

CVEs

Events, n/total

Hazard ratio (95% CI)

Crude model

Adjusted model

Non-TX/CA

24/200

1 (reference)

1 (reference)

TX/CA

11/50

2.86 (1.37–5.98)**

2.75 (1.04–7.26)*

Group1 TX/CA (−) Mu (−)

12/108

1 (reference)

1 (reference)

Group2 TX/CA (−) Mu (+)

12/92

1.07 (0.48–2.39)

0.82 (0.34–1.98)

Group3 TX/CA (+) Mu (−)

1/14

1.01 (0.13–7.89)

1.02 (0.12–8.49)

Group4 TX/CA (+) Mu (+)

10/36

3.66 (1.55–8.64)**

3.34 (1.04–10.72)*

  1. Adjusted model was adjusted for age, sex, BMI, CAD, smoking, hypertension, DM, family history of CAD, adjusted LDL-C levels, lipid-lowering therapy, LDL cholesterol year score and total cholesterol year score
  2. TX: tendon xanthomas; CA: corneal arcus; Mu: mutation; Mu (+), mutation positive; Mu (−), mutation negative
  3. *p < 0.05, **p < 0.01
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Journal of Translational Medicine

ISSN: 1479-5876

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