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Table 2 Regression analyses to assess the association between TX/CA and genetic mutations in patients with HeFH after propensity score matching

From: Relations of physical signs to genotype, lipid and inflammatory markers, coronary stenosis or calcification, and outcomes in patients with heterozygous familial hypercholesterolemia

Characteristics No mutation LDLR (−) LDLR (+)
Model 1 ORs 1 (Reference) 0.827 (0.222–3.077) 3.978 (1.980–7.989)
p value   0.776  < 0.001
Model 2 ORs 1 (Reference) 0.810 (0.217–3.021) 4.193 (2.060–8.534)
p value   0.754  < 0.001
Model 3 ORs 1 (Reference) 0.919 (0.190–4.451) 3.493 (1.442–8.465)
p value   0.917 0.006
  1. Model 1 unadjusted, model 2 age- and sex- adjusted, model 3 fully adjusted for age, sex, BMI, CAD, smoking, hypertension, DM, family history of CAD, uncontrolled LDL-C levels, lipid-lowering therapy, total cholesterol year score and LDL cholesterol year score. Bold values indicate statistical significance
  2. LDLR: low-density lipoprotein receptor; LDLR (−): LDLR negative mutation; LDLR (+): LDLR positive mutation; OR: odds ratio; BMI: body mass index; CAD: coronary artery disease; DM: diabetes mellitus