Skip to main content
Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia

Fig. 2

Assessment of systolic and diastolic function. The decline of systolic function was more pronounced in males, while diastolic function deteriorated to a greater degree in females after isoproterenol treatment. A, B Contractility as assessed by EF and PRSW markedly decreased in males after ischemia. D Accordingly, MAP significantly decreased in males as well. E The observed deterioration of systolic function of males was underlain by a marked decline in cardiac efficiency. C Marked increase in Tau indicated a more pronounced worsening of active relaxation in females. F Diastolic stiffness increased only in females as determined by EDPVR. Statistical significance of post hoc test compared to same-sex control is highlighted as follows: *P < 0.05, **P < 0.01, ***P < 0.001. M-Co: male control; M-Isch: male ischemic; F-Co female control; F-Isch: female ischemic; EF: ejection fraction; PRSW: preload recruitable stroke work; MAP: mean arterial pressure; EDPVR: slope of the LV end-diastolic pressure–volume relationship

Back to article page