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Table 3 Univariable and Multivariable analyses of covariable associated with OS

From: Effect of brain radiotherapy strategies on prognosis of patients with EGFR-mutant lung adenocarcinoma with brain metastasis

 

Univariable analysis

Multivariable analysis

Variable

HR

95% CI

P

HR

95% CI

P

Age (y)

 < 60 vs ≤ 60

0.959

0.684 to 1.344

0.807

   

Sex

 Female vs male

1.014

0.733to 1.402

0.935

   

Smoking status

 Never vs current/former

1.136

0.786 to 1.643

0.497

   

EGFR mutation

 Exon 19

0.721

0.520 to 1.000

0.050

0.800

0.495 to 1.292

0.362

 Exon 21

1.252

0.914 to 1.715

0.161

1.104

0.693 to 1.104

0.678

First-line TKI therapy

 Yes v no

1.480

1.077 to 2.032

0.016

1.358

0.985 to 1.872

0.061

Lung-molGPA

      

 1–2 v 2.5–4

0.513

0.374 to 0.703

 < 0.001

0.606

0.433 to 0.849

0.004

Radiotherapy strategies

 WBRT

1.835

1.326 to 2.539

 < 0.001

1.529

1.084 to 2.157

0.016

 Local radiotherapy

0.456

0.299 to 0.694

 < 0.001

0.530

0.340 to 0.827

0.005

 WBRT + Boost

0.623

0.434 to 0.894

0.010

0.744

0.509 to 1.087

0.126

Brain metastatic time

 Initial treatment vs In the course of treatment

1.083

0.923 to 1.271

0.329

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