Fig. 1

Bacterial diversity of normal and tumor tissues in CRC patients. a The α-diversity estimated by the Shannon index and observed OTUs. b (left) The β-diversity estimated using PCoA of OTUs. (right) Distribution of Bray–Curtis distances of OTUs in normal samples (N–N), tumor samples (T-T), and normal and tumor samples (N-T). c LEfSe plot illustrating microbial taxa enriched in normal compared with CRC tumor tissues. N: normal, T: tumor