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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype

Fig. 7

CD226 modulates the ATM polarization under a model of HFD-induced obesity. CD226 affects macrophage accumulation in adipose tissues and mediates macrophage M1 polarization. Proinflammatory M1-type ATMs induce the development of inflammation within adipose tissue and contribute to systemic inflammatory state, including fatty liver, by secreting proinflammatory cytokines through PPAR-γ-dependent signaling, which leads to the occurrence and progress of obesity

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Journal of Translational Medicine

ISSN: 1479-5876

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