Fig. 5

Deficiency of CD226 regulated macrophage M1/M2 polarization. A mRNA levels of M1/M2-type cytokines, Ccl3, Cxcl14, Cxcl16, and PPAR-γ in LPS-stimulated peritoneal macrophages from WT and CD226KO mice (n = 3). B Glycolytic activity of LPS-stimulated peritoneal macrophages from WT and CD226KO mice. Combined data from three independent experiments (n = 3). C ROS production in LPS-stimulated peritoneal macrophages from WT and CD226KO mice (n = 3). Data represent mean ± SEM. Differences between groups were determined by unpaired Student’s t-test. *P < 0.05, **P < 0.01