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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype

Fig. 2

Obesity was ameliorated in HFD-fed CD226KO mice. A Representative images of WT and CD226KO mice fed with a HFD for 16 weeks (n = 6). B Bodyweight of WT and CD226KO mice fed with either chow or a HFD for 16 weeks (n = 4). C Representative H&E staining and perilipin-1 immunofluorescence staining of epididymal fat of WT and CD226KO mice fed with either chow or a HFD for 16 weeks (n = 4). Scale bar means 100 μm. D Adipocyte size and measurements of epididymal fat of WT and CD226KO mice fed with either chow or a HFD for 16 weeks. (n = 4). E, F Representative H&E images and islet size measurement of pancreatic tissue of WT and CD226KO mice fed with either chow or a HFD for 16 weeks. Scale bar means 100 μm. G Serum concentrations of triglyceride, HDL-C, LDL-C, and total cholesterol (n = 4). Graphs or combined data from three independent experiments. Data represent mean ± SEM. Differences between groups were determined by one way ANOVA with Tukey’s multiple test. *P < 0.05, **P < 0.01

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