Fig. 1

The dispersion of AUCs and STAT scores of acute radiotoxicity endpoints in HNC patients by discovery and replication cohorts. The X-axis shows the endpoints, and Y-axes show the measured value of the AUC and STAT score of endpoints. The Brown color represents the discovery study, and the grey color represents the replication study. The black border shows physician-rated endpoints, and the orange border shows patient-rated endpoints. The lowest line represents the minimum (Q0 or 0th percentile): the top line represents the maximum (Q4 or 100th percentile) data point excluding any outliers; The middle line represents the median (Q2 or 50th percentile); the box represents the interquartile range (IQR) which is the distance between the first quartile (Q1 or 25th percentile; that is the median of the lower half of the dataset) and the third quartile (Q3 or 75th percentile that is the median of the upper half of the dataset). Table 2 shows the comparison between discovery and replication studies for the significant difference in outcomes’ distribution