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Table 1 Characteristics of the individuals recruited in the Nested Case–Control Study of the EURODIAB PCS

From: MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS

 

Case subjects

(n = 294)

Control subjects

(n = 153)

P value

Age (years)

41.60 ± 10.70

35.50 ± 7.50

 < 0.001

Sex (M/F%)

53/47

48/52

0.35

BMI (Kg/m2)

24.80 ± 3.60

23.80 ± 2.60

0.001

Diabetes duration (years)

24.95 ± 9.23

15.31 ± 7.12

 < 0.001

A1C (%)

9.02 ± 1.61

7.77 ± 1.19

 < 0.001

Systolic BP (mmHg)

127.30 ± 22.20

114.60 ± 13.50

 < 0.001

Diastolic BP (mmHg)

75.90 ± 11.40

73.50 ± 10.80

0.030

Current smoker (%)

32.90

28.10

0.01

Hypertension (%)

55.80

13.40

 < 0.001

eGFR (ml/min/1.73m2)

90.31 ± 25.04

106.20 ± 13.74

 < 0.001

Total cholesterol (mmol/l)

5.48 ± 1.23

4.90 ± 1.09

 < 0.001

LDL-cholesterol (mmol/l)

3.35 ± 1.11

2.79 ± 0.97

 < 0.001

HDL-cholesterol (mmol/l)

1.60 ± 0.42

1.66 ± 0.40

0.157

Triglycerides (mmol/l)

1.19 (0.82–1.58)

0.82 (0.64–1.08)

 < 0.001

NT-proBNP (pg/ml)

76.31 (31.34–133.50)

41.10 (22.57–75.48)

 < 0.001

TNF-α (pg/ml)

3.27 (2.40–4.30)

2.21 (1.72–2.85)

 < 0.001

IL-6 (pg/ml)

2.50 (1.33–3.79)

1.80 (1.17–2.55)

 < 0.001

miR-146a-5p

1.15 (0.32–3.34)

1.74 (0.44–6.73)

0.039

  1. Data are expressed as mean ± SD, percentage or geometric mean (25°-75° percentile) for log-transformed data. BMI, body mass index; LDL, low-density lipoprotein; HDL, high-density lipoprotein; BP, blood pressure; eGFR, estimated glomerular filtration rate; NT-proBNP, NT-proB-type Natriuretic Peptide; IL-6, interleukin 6; TNF-α, tumor necrosis factor alpha