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Table 1 Characteristics of the individuals recruited in the Nested Case–Control Study of the EURODIAB PCS

From: MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS

  Case subjects
(n = 294)
Control subjects
(n = 153)
P value
Age (years) 41.60 ± 10.70 35.50 ± 7.50  < 0.001
Sex (M/F%) 53/47 48/52 0.35
BMI (Kg/m2) 24.80 ± 3.60 23.80 ± 2.60 0.001
Diabetes duration (years) 24.95 ± 9.23 15.31 ± 7.12  < 0.001
A1C (%) 9.02 ± 1.61 7.77 ± 1.19  < 0.001
Systolic BP (mmHg) 127.30 ± 22.20 114.60 ± 13.50  < 0.001
Diastolic BP (mmHg) 75.90 ± 11.40 73.50 ± 10.80 0.030
Current smoker (%) 32.90 28.10 0.01
Hypertension (%) 55.80 13.40  < 0.001
eGFR (ml/min/1.73m2) 90.31 ± 25.04 106.20 ± 13.74  < 0.001
Total cholesterol (mmol/l) 5.48 ± 1.23 4.90 ± 1.09  < 0.001
LDL-cholesterol (mmol/l) 3.35 ± 1.11 2.79 ± 0.97  < 0.001
HDL-cholesterol (mmol/l) 1.60 ± 0.42 1.66 ± 0.40 0.157
Triglycerides (mmol/l) 1.19 (0.82–1.58) 0.82 (0.64–1.08)  < 0.001
NT-proBNP (pg/ml) 76.31 (31.34–133.50) 41.10 (22.57–75.48)  < 0.001
TNF-α (pg/ml) 3.27 (2.40–4.30) 2.21 (1.72–2.85)  < 0.001
IL-6 (pg/ml) 2.50 (1.33–3.79) 1.80 (1.17–2.55)  < 0.001
miR-146a-5p 1.15 (0.32–3.34) 1.74 (0.44–6.73) 0.039
  1. Data are expressed as mean ± SD, percentage or geometric mean (25°-75° percentile) for log-transformed data. BMI, body mass index; LDL, low-density lipoprotein; HDL, high-density lipoprotein; BP, blood pressure; eGFR, estimated glomerular filtration rate; NT-proBNP, NT-proB-type Natriuretic Peptide; IL-6, interleukin 6; TNF-α, tumor necrosis factor alpha