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Table 1 Demographic and clinical characteristics of the study participants

From: Gene profiling of Toll-like receptor signalling pathways in neutrophils of patients with acute-on-chronic liver failure

Variables Health controls
(n = 9)
Compensated cirrhosis
(n = 9)
De-compensated cirrhosis
(n = 9)
ACLF
(n = 9)
Male/female 6/3 5/4 6/3 6/3
Age 53.4 ± 3.7 54.4 ± 6.7 58.3 ± 12.4 47.3 ± 10.9
Aetiologies of cirrhosis
 HBV 0 7 6 8
 Non-HBV 9 2 3 1
De-compensation events
 Ascites 0 6 2
 UGH 0 3 1
 HE 0 0 0
 Jaundice 0 0 9
Organ failure    
 Liver failure 0 0 9
 Coagulation failure 0 0 6
 Kidney failure 0 0 0
 Cerebral failure 0 0 0
 Circulation failure 0 0 0
 Lung failure 0 0 0
WBC (109/L) 5.4 (3.5) 4.2 (2.8) 2.1 (2.8) 7.4 (7.1)
PLT (109/L) 123 (24) 89 (111) 60.5 (57) 109 (58)
TB (umol/L) 6 (3.4) 14 (15.5) 19.5 (19.5) 368 (135.3)
INR 1 (0.1) 1.1 (0.1) 1.4 (0.5) 2.6 (0.9)
Creatinine(umol/l) 78 (22) 64 (20) 68 (12) 66 (30.8)
Albumin(g/L) 43 (5.7) 40.3 (11.2) 33 (9.8) 31.7 (5.6)
MELD score 5.3 (7.4) 8.5 (7) 25 (5)
CLIF-C ACLFs 41.5 (8.3)
  1. HBV hepatitis B virus, UGH upper gastrointestinal haemorrhage, HE hepatic encephalopathy, Jaundice TBil ≥ 85 µmol/L, WBC white blood cell, PLT platelet, TB total bilirubin, INR: international normalized ratio, MELD model for end-stage liver disease,CLIF-C ACLFs Chronic liver failure Consortium Acute-on-chronic liver failure scores