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Table 1 Demographic and clinical characteristics of the study participants

From: Gene profiling of Toll-like receptor signalling pathways in neutrophils of patients with acute-on-chronic liver failure

Variables

Health controls

(n = 9)

Compensated cirrhosis

(n = 9)

De-compensated cirrhosis

(n = 9)

ACLF

(n = 9)

Male/female

6/3

5/4

6/3

6/3

Age

53.4 ± 3.7

54.4 ± 6.7

58.3 ± 12.4

47.3 ± 10.9

Aetiologies of cirrhosis

 HBV

0

7

6

8

 Non-HBV

9

2

3

1

De-compensation events

 Ascites

0

6

2

 UGH

0

3

1

 HE

0

0

0

 Jaundice

0

0

9

Organ failure

   

 Liver failure

0

0

9

 Coagulation failure

0

0

6

 Kidney failure

0

0

0

 Cerebral failure

0

0

0

 Circulation failure

0

0

0

 Lung failure

0

0

0

WBC (109/L)

5.4 (3.5)

4.2 (2.8)

2.1 (2.8)

7.4 (7.1)

PLT (109/L)

123 (24)

89 (111)

60.5 (57)

109 (58)

TB (umol/L)

6 (3.4)

14 (15.5)

19.5 (19.5)

368 (135.3)

INR

1 (0.1)

1.1 (0.1)

1.4 (0.5)

2.6 (0.9)

Creatinine(umol/l)

78 (22)

64 (20)

68 (12)

66 (30.8)

Albumin(g/L)

43 (5.7)

40.3 (11.2)

33 (9.8)

31.7 (5.6)

MELD score

5.3 (7.4)

8.5 (7)

25 (5)

CLIF-C ACLFs

41.5 (8.3)

  1. HBV hepatitis B virus, UGH upper gastrointestinal haemorrhage, HE hepatic encephalopathy, Jaundice TBil ≥ 85 µmol/L, WBC white blood cell, PLT platelet, TB total bilirubin, INR: international normalized ratio, MELD model for end-stage liver disease,CLIF-C ACLFs Chronic liver failure Consortium Acute-on-chronic liver failure scores