Fig. 5

Effectiveness of RB-340-1 administered intravenously against FaDu xenografts. A RB-340-1 anti-tumor activity against FaDu xenografts growth—average tumor growth was followed till day 29 (data shown for 1 M dose of CAR-T cell); B after day 29, mice in control groups began to die and average growth is not informative. Scatter plots were subsequently used as exemplified for day 29 for the 1 M dosage group. C RB-340-1 effect on survival of individual mice and D cumulative survival for the 1 M dose; E RB-340-1 effect on survival of individual mice and F cumulative survival for the 3 M dose. G intratumoral persistence of hCD45⁺ CAR-T cells and H percentage of PD-1 expressing hCD45⁺ CAR-T cells at necropsy