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Table 3 Minimally clinical important difference change (MCID) for outcomes

From: Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

  Active Sham Fisher’s exact
P-value
N n (%) N n (%)
Primary outcomes
 ≥ 2 points OR ≥ 30%* 31 9 (29%) 34 6 (18%) 0.131
Secondary outcomes
 EQ-VAS ≥ 11 31 12 (39%) 34 7 (21%) 0.061
 EQ 5D-Index ≥ 0.145 31 14 (45%) 34 10 (29%) 0.088
 BPI I ≥ 2 31 9 (29%) 34 6 (18%) 0.131
Exploratory outcomes
 BPI W ≥ 3* 31 8 (26%) 34 5 (15%) 0.134
 HADS Anxiety ≥ 4** 31 8 (26%) 34 5 (15%) 0.134
 HADS Depression ≥ 4 ** 31 6 (19%) 34 2 (6%) 0.082
 PSEQ ≥ 7 ** 31 9 (29%) 34 6 (18%) 0.131
 DMA mapped area ≥ *** 31 16 (52%) 34 10 (29%) 0.039
Total mean 31 33% (± 11) 34 19% (± 7.1) 0.005¥
  1. EQ-VAS: EuroQol visual analogue score; EQ-5D Index: EQ-5D-5L index score (utility); BPI I: Brief pain inventory interference subscale; BPI W: Brief pain inventory worst pain intensity; HADS anxiety: Hospital anxiety scale anxiety subscale; HADS depression: Hospital anxiety scale depression subscale; PSEQ: Pain self-efficacy questionnaire; DMA mapped area: Dynamic allodynia mapped area;  ± standard deviation, ¥ Mann Whitney
  2. * % change based on pain score at baseline
  3. ** Also met additional criteria of movement to different severity category
  4. ***  > 20% change based on area at baseline