Fig. 3

Mechanistic study outcomes: Suppression of mechanically evoked pain by LFS in the clinically affected area. A Mechanical pain sensitivity: A series of pain ratings in response to repeated sets of pinprick stimulations spaced approximately 5 min from each other, within the clinically affected area in patients who participated in the mechanistic study (n = 19). Data depict baseline ratings preceding low frequency stimulation (LFS), followed by LFS (no rating), and ratings to testing following LFS. B Dynamic mechanical allodynia (Pain to light touch): Means of pain ratings following stroking touch stimuli of the affected skin, before and after LFS in patients who exhibited DMA prior to LFS (n = 15). C Area of mechanical hyperalgesia: Means of diameter of area of mechanical hyperalgesia mapped by a punctate stimulus before and after LFS (n = 19). A–C Where *p ≤ 0.05 **p ≤ 0.01, comparing pre- to post-LFS pain ratings, Vertical error bars represent SEM