Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration

Lin, Hongbing; Chen, Huishan; Zhao, Xuetao; Chen, Zhen; Zhang, Peipei; Tian, Yue; Wang, Yawei; Ding, Tong; Wang, Lijing; Shen, Yuqin

doi:10.1186/s12967-021-03125-5

Table 1 Periodontal regeneration-related in vitro biological activities of MSC-CM

From: Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration

S. No.	Source of MSC-CM	Cell type	Biological activity	Refs.
Bone regeneration
1	hASCs	hPDLSCs	Upregulates osteoblastic gene expression in hPDLSCs	[90]
2	hBMSCs	hPDLSCs	Triggers osteogenesis of hPDLSCs	[87]
3	Healthy or inflamed PDLSCs	‘Inflamed’ PDLSCs	Healthy PDLSCs-CM rescues impaired-differentiation of inflamed-PDLSCs	[122]
Cementum regeneration
1	hMSCs	Dog MSCs and dog PDLSCs	Promotes dog MSCs and dog PDLSCs proliferation and migration	[91]
2	rAPTGs	hGMSCs	Promotes differentiation of hGMSCs along the cementoblastic lineage	[85]
3	rDFCs	ASCs	Promotes ASCs towards cementoblast-like cells	[88]
4	rAPTGs	hPDLSCs	Promotes hPDLSCs towards cementoblast-like cells	[123]
Angiogenesis
1	hMSCs	rMSCs	Increases angiogenesis	[82]
2	hMSCs	Human umbilical vein endothelial cells (HUVECs)	Promotes angiogenesis and migration of HUVECs	[103]
3	equine-PB-MSCs	ECs	Induces angiogenesis in equine vascular ECs	[106]
4	mMSCs and hEPCs	HUVECs	Promotes cell adhesion and proliferation	[107]
Immunomodulatory and anti-inflammatory
1	hPDLSCs	RAW 264.7	Inhibits TNF-α expression	[83]
2	rPDLSCs	rBMDMs	Induces macrophage polarization towards the M2 phenotype	[111]
3	hPDLSCs	THP-1	Induces M1 macrophage polarization	[124]
Chemotaxis
1	hMSCs	Dog BMSCs and dog PDLSCs	Enhances migration and proliferation of dMSCs and dPDLCs	[91]
2	hBMSCs	HUVECs	Promotes functional angiogenic effects	[97]
3	hMSCs and canine MSCs	ECs	Increases EC migration, proliferation and the formation of tubule-like structures	[102]
4	mMSCs	Dermal fibroblast	Induces dermal fibroblast migration	[118]
5	mMSCs	RAW264.7	Enhances the chemotaxis of RAW264 cells	[119]
6	hMSCs	Human dermal lymphatic ECs	Stimulates proliferation, migration, and tube formation of lymphatic ECs	[120]

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