From: DEL in China: the D antigen among serologic RhD-negative individuals
Allele description | ISBT name | Mechanism | Amino acid changes | Haplotype | Frequency in Hanc among | Reports | ||
---|---|---|---|---|---|---|---|---|
Adsorption-elution positive | Rh-negative | In China | Outside China | |||||
RHD(1227G>A)a | RHD*DEL1 | Splice site variant | K409K | CDe | 96.7%d | 21.6%d | 13 studiesd | |
RHD(3G>A) | RHD*DEL2 | Loss of start codon | M1I | N/R | 1.11% | 0.25% | N/R | |
RHD-CE(4–9)-D | RHD*DEL44 | Hybrid allele | hybrid protein | CDe | 0.71% | 0.16% | N/R | |
RHD-CE(2–5)-D | N/A | Hybrid allele | hybrid protein | N/R | 0.55% | 0.12% | N/R | |
RHD(28C>T) | RHD*01 W.61 | Single nucleotide variant | R10W | CDe | 0.16% | 0.04% | GenBank:AM412754 | |
RHD(53T>C) | RHD*DEL3 | Single nucleotide variant | L18P | N/R | 0.16% | 0.04% | N/R | |
RHD(251T>C) | RHD*DEL6 | Single nucleotide variant | L84P | N/R | 0.16% | 0.04% | N/R | |
RHD-CE(4–7)-Db | RHD*01 N.07 | Hybrid allele | hybrid protein | cDE | 0.16% | 0.04% | ||
RHD(93T>A) | N/A | Single nucleotide variant | F31L | CDe | 0.08% | 0.02% | 1 study [29] | N/R |
RHD(410C>A) | RHD*DEL7 | Single nucleotide variant | A137E | CDe | 0.08% | 0.02% | 1 study [28] | N/R |
RHD(838G>A) | RHD*DEL24 | Single nucleotide variant | A280T | N/R | 0.08% | 0.02% | 1 study [29] | N/R |
RHD(IVS7+152C>A,1227G>A) | RHD*DEL36 | Splice site variant | K409K | CDe | 0.08% | 0.02% | 1 study [17] | N/R |
RHD-RHCE(10) | N/A | Hybrid allele | none | CDe | 0.08% | 0.02% | 1 study [28] |