Fig. 2

Prevalence of RhD-negative and DEL in clinical cohorts in China per year. The number of individuals with DEL who seek medical care every year, are estimated for the 3 clinical cohorts of transfused patients (upper row), pregnant women (middle row), and blood donors (lower row). Pie charts symbolize the total number (left column), serologic RhD-negative (second column), DEL phenotype (third column), and Asian type DEL (right column). Among the total number of individuals (orange, not to scale), the RhD-negative (blue) represent 0.30% (see Table 2). Approximately 23.3% (see Table 3) of the serologic RhD-negative carry a DEL phenotype (green). The vast majority (96.7%, see Table 4) of all DEL alleles (causing a DEL phenotype) is represented by the Asian type DEL (yellow). The small fraction of other DEL alleles (red) has a cumulative frequency of 3.3% (see Table 4)