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Table 1 Correlation between circ-ERBB2 expression and clinical characteristics in breast cancer patients

From: Circular RNA circ-ERBB2 promotes HER2-positive breast cancer progression and metastasis via sponging miR-136-5p and miR-198

Clinicopathologic parameters N circ-ERBB2 expression p-value
Low (%) High (%)
Age (years)
 ≤ 40 8 3 (37.5%) 5 (62.5%) 0.750
 > 40 35 18 (51.4%) 17 (48.6%)
Tumor size (cm)
 ≤ 2 30 13 (43.3%) 17 (56.7%) 0.332
 > 2 13 8 (61.5%) 5 (38.5%)
Lymph node metastasis
 Negative 20 14 (70.0%) 6 (30.0%) 0.010*
 Positive 23 7 (30.4%) 16 (69.6%)
Histological grade
 I 11 7 (63.6%) 4 (36.4%) 0.214
 II 14 8 (57.1%) 6 (42.9%)
 III 18 6 (33.3%) 12 (66.7%)
TNM stage
 I 10 8 (80.0%) 2 (20.0%) 0.090
 II 16 8 (50.0%) 8 (50.0%)
 III 13 4 (30.8%) 9 (69.2%)
IV 4 1 (25.0%) 3 (75.0%)
HER2 status
 Negative 20 15 (75.0%) 5 (25.0%) 0.001**
 Positive 23 6 (26.1%) 17 (73.9%)
  1. TNM: tumor-node-metastasis
  2. *P<0.05
  3. **P<0.01