Table 1 Clinicopathological features of 22 tumors harboring gene fusions detected by either DNA or RNA next generation sequencing
Case No. | Fusion type | Clinical feature | Histological feature | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Age | Gender | Tumor location | TNM | AJCC stage | Tumor differentiation | Mucinous differentiation | Lymphovascular invasion | Perineural invasion | ||
1 | TPM3(e7)–NTRK1(e10) | 61 | Female | Ileocecum | T2N1bM0 | II | Moderate–poor | Yes | No | No |
2 | TPM3(e7)–NTRK1(e10) | 83 | Female | Hepatic flexure | T3N1bM0 | III | Moderate–poor | No | Yes | No |
3 | TPM3(e7)–NTRK1(e10) | 77 | Male | Hepatic flexure | T3N0M0 | II | Moderate–low | Yes | No | No |
4 | TPM3(e7)–NTRK1(e9) | 69 | Female | Hepatic flexure | T3N0M0 | II | Low | No | Yes | No |
5 | TPM3(e5)–NTRK1(e11) | 76 | Female | Hepatic flexure | T4aN2aM0 | III | Low | No | Yes | Yes |
6 | TPM3(e7)–NTRK1(e9) | 83 | Female | Ascending colon | T2N0M0 | II | Low | No | No | Yes |
7 | LMNA(e9)–NTRK1(e12) | 75 | Female | Ascending colon | T3N2bM0 | III | Moderate–low | No | Yes | No |
8 | LMNA(e10)–NTRK1(e10) | 82 | Female | Ascending colon | T3N1cM0 | III | Moderate–low | Yes | Yes | No |
9 | PLEKHA6(e22)–NTRK1(e10) | 75 | Female | Transverse colon | T3N1cM0 | III | Moderate | No | Yes | No |
10 | ETV6(e5)–NTRK3(e15) | 55 | Male | Descending colon | T3N0M0 | II | High | Yes | No | No |
11 | ETV6(e5)–NTRK3(e15) | 59 | Male | Hepatic flexure | T3N0M0 | II | High–moderate | No | Yes | No |
12 | ETV6(e5)–NTRK3(e15) | 53 | Male | Hepatic flexure | T4aN0M0 | II | Moderate–low | No | Yes | Yes |
13 | EML4(e2)–NTRK3(e14) | 75 | Male | Hepatic flexure | T3N0M0 | II | Moderate | Yes | No | No |
14 | EML4(e2)–NTRK3(e14) | 77 | Female | Ascending colon | T3N0M0 | II | Moderate | Yes | No | No |
15 | STRN(e3)–ALK(e20) | 69 | Female | Hepatic flexure | T3N0M0 | II | Moderate–poor | No | Yes | No |
16 | STRN(e3)–ALK(e20) | 69 | Female | Ascending colon | T2N0M0 | II | Moderate | Yes | No | No |
17 | EML4(e2)–ALK(e19) | 62 | Female | Hepatic flexure | T3N1bM0 | III | Moderate–poor | No | Yes | No |
18 | NCOA4(e11)–RET(e12) | 71 | Female | Hepatic flexure | T3N0M0 | II | Moderate | Yes | No | No |
19 | NCOA4(e11)–RET(e12) | 82 | Male | Hepatic flexure | T3N0M0 | II | Moderate–low | No | No | No |
20 | SNRNP70(e8)–MET(e15) | 82 | Male | Hepatic flexure | T3N0M0 | II | Moderate–low | Yes | No | No |
21 | CUL1(e7)–BRAF(e9) | 75 | Male | Splenic flexure | T3N0M0 | II | Moderate | No | No | No |
22 | YPEL1(e1)–MAPK1 (e5) | 79 | Male | Hepatic flexure | T3N0M0 | II | Moderate | No | No | No |