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Table 1 Clinicopathological features of 22 tumors harboring gene fusions detected by either DNA or RNA next generation sequencing

From: Comprehensive analysis of oncogenic fusions in mismatch repair deficient colorectal carcinomas by sequential DNA and RNA next generation sequencing

Case No. Fusion type Clinical feature Histological feature
Age Gender Tumor location TNM AJCC stage Tumor differentiation Mucinous differentiation Lymphovascular invasion Perineural invasion
1 TPM3(e7)–NTRK1(e10) 61 Female Ileocecum T2N1bM0 II Moderate–poor Yes No No
2 TPM3(e7)–NTRK1(e10) 83 Female Hepatic flexure T3N1bM0 III Moderate–poor No Yes No
3 TPM3(e7)–NTRK1(e10) 77 Male Hepatic flexure T3N0M0 II Moderate–low Yes No No
4 TPM3(e7)–NTRK1(e9) 69 Female Hepatic flexure T3N0M0 II Low No Yes No
5 TPM3(e5)–NTRK1(e11) 76 Female Hepatic flexure T4aN2aM0 III Low No Yes Yes
6 TPM3(e7)–NTRK1(e9) 83 Female Ascending colon T2N0M0 II Low No No Yes
7 LMNA(e9)–NTRK1(e12) 75 Female Ascending colon T3N2bM0 III Moderate–low No Yes No
8 LMNA(e10)–NTRK1(e10) 82 Female Ascending colon T3N1cM0 III Moderate–low Yes Yes No
9 PLEKHA6(e22)–NTRK1(e10) 75 Female Transverse colon T3N1cM0 III Moderate No Yes No
10 ETV6(e5)–NTRK3(e15) 55 Male Descending colon T3N0M0 II High Yes No No
11 ETV6(e5)–NTRK3(e15) 59 Male Hepatic flexure T3N0M0 II High–moderate No Yes No
12 ETV6(e5)–NTRK3(e15) 53 Male Hepatic flexure T4aN0M0 II Moderate–low No Yes Yes
13 EML4(e2)–NTRK3(e14) 75 Male Hepatic flexure T3N0M0 II Moderate Yes No No
14 EML4(e2)–NTRK3(e14) 77 Female Ascending colon T3N0M0 II Moderate Yes No No
15 STRN(e3)–ALK(e20) 69 Female Hepatic flexure T3N0M0 II Moderate–poor No Yes No
16 STRN(e3)–ALK(e20) 69 Female Ascending colon T2N0M0 II Moderate Yes No No
17 EML4(e2)–ALK(e19) 62 Female Hepatic flexure T3N1bM0 III Moderate–poor No Yes No
18 NCOA4(e11)–RET(e12) 71 Female Hepatic flexure T3N0M0 II Moderate Yes No No
19 NCOA4(e11)–RET(e12) 82 Male Hepatic flexure T3N0M0 II Moderate–low No No No
20 SNRNP70(e8)–MET(e15) 82 Male Hepatic flexure T3N0M0 II Moderate–low Yes No No
21 CUL1(e7)–BRAF(e9) 75 Male Splenic flexure T3N0M0 II Moderate No No No
22 YPEL1(e1)–MAPK1 (e5) 79 Male Hepatic flexure T3N0M0 II Moderate No No No