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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse

Fig. 7

The transcriptomic effect of Cyp17 overexpression is the TC17 ovary. RNA sequencing reveals Cyp17 effect on ovary gene regulation. A Upon Cyp17 induction, 721 genes were upregulated, and 290 genes were downregulated (adj. p-value < 0.05). B Among these genes, well-known ovary morphogenesis transcriptional regulators such as Cyp11, Prlr were upregulated, while Ihh and Runx1 were downregulated. Volcano plot indicates the relative fold change and p-value of genes in B. C GO analysis of the 1011 differentially expressed genes included terms such as extracellular matrix and collagen-containing extracellular matrix (see Additional file 1: Figure S4 for full-term list). D–E The induction and repression of Lhcgr and Fshr respectively, as found by RNA-seq, were confirmed using qPCR

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