Fig. 7From: Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouseThe transcriptomic effect of Cyp17 overexpression is the TC17 ovary. RNA sequencing reveals Cyp17 effect on ovary gene regulation. A Upon Cyp17 induction, 721 genes were upregulated, and 290 genes were downregulated (adj. p-value < 0.05). B Among these genes, well-known ovary morphogenesis transcriptional regulators such as Cyp11, Prlr were upregulated, while Ihh and Runx1 were downregulated. Volcano plot indicates the relative fold change and p-value of genes in B. C GO analysis of the 1011 differentially expressed genes included terms such as extracellular matrix and collagen-containing extracellular matrix (see Additional file 1: Figure S4 for full-term list). D–E The induction and repression of Lhcgr and Fshr respectively, as found by RNA-seq, were confirmed using qPCRBack to article page