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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse

Fig. 5

Follicular morphology assessment of TC17 ovaries. After Dox treatment (8 weeks), CTRL and TC17 mice were sacrificed, and ovaries were collected, and histological assessment was performed (N = 6). A–E Primary follicles (A), secondary follicles (B), antral follicles (C), corpora lutea (D) and atretic-cystic/collapsed clusters (E) were quantified in TC17 and CTRL mice, means ± s.e.m. F Histological scores of hypertrophic stromal morphologies stained with H&E at the end of the treatment (0–1 = normal; 2 = mild hypertrophy; 3 = severe hypertrophy), means ± s.e.m. Data were analyzed using the two-tailed Mann–Whitney test (*p < 0.05, **p < 0.01). G Representative images of hyperstromatic follicles (top panel), an atretic follicle (middle panel) and a collapsed cluster (bottom panel)

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