Fig. 5From: Effect of the spatial–temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouseFollicular morphology assessment of TC17 ovaries. After Dox treatment (8 weeks), CTRL and TC17 mice were sacrificed, and ovaries were collected, and histological assessment was performed (N = 6). A–E Primary follicles (A), secondary follicles (B), antral follicles (C), corpora lutea (D) and atretic-cystic/collapsed clusters (E) were quantified in TC17 and CTRL mice, means ± s.e.m. F Histological scores of hypertrophic stromal morphologies stained with H&E at the end of the treatment (0–1 = normal; 2 = mild hypertrophy; 3 = severe hypertrophy), means ± s.e.m. Data were analyzed using the two-tailed Mann–Whitney test (*p < 0.05, **p < 0.01). G Representative images of hyperstromatic follicles (top panel), an atretic follicle (middle panel) and a collapsed cluster (bottom panel)Back to article page