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Table 1 The functions of PECs

From: The recruitment mechanisms and potential therapeutic targets of podocytes from parietal epithelial cells

Useful functionality Harmful functionality
1. Progenitor function for podocytes 1. Abnormal proliferation leads to crescentic glomerulonephritis and collapsing glomerulopathy
2. Intracellular tight junctions restrict glomerular filtrate to urinary space 2. Participate in glomerular scarring
3. Possible synthesis and repair of Bowman’s basement membrane