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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: The role of PDGFRA as a therapeutic target in young colorectal cancer patients

Fig. 2

Differential mRNAs expression and gene profiling between young CRC and old CRC tissue. a Volcano plot of differentially expressed genes. Significant genes are highlighted in red. Dotted lines indicate cutoff values of log2 fold change (FC) ≥  ± 1, FDR ≤ 0.05. b Venn diagram of differentially expressed genes between young and old age groups. The number of genes obtained after a comparison with normal samples (right) and with tumor samples (left). c Heatmap of the expression profile of selected genes. The expression values were normalized by a z-score transformation across samples. d Enriched pathways from significantly changed genes in expression. e Oncoprint of CRC-associated mutations (missense, nonsense, and splicing). f Copy number amplification and deletions that are frequently detected in the samples. The green solid line indicates the q-value cutoff = 0.01

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