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Table 2 Univariate and multivariate Cox regression analyses of CENPA mRNA level and patient overall survival (OS)

From: CENPA promotes clear cell renal cell carcinoma progression and metastasis via Wnt/β-catenin signaling pathway

Variable

Univariate analysis

Multivariate analysisc

 

HRa

95% CIb

P

HR

95% CI

P

Overall survival (n = 522)

      

CENPA

 Low (n = 261)

2.384

1.722–3.3

0.003

1.656

1.17–2.344

0.004

 High (n = 261)

Age

 < 60 (n = 235)

1.641

1.196–2.252

0.002

1.391

1.003–1.928

0.048

 ≥ 60 (n = 287)

Gender

 Female (n = 183)

1.071

0.783–1.464

0.669

1.239

0.894–1.717

0.198

 Male (n = 339)

T stage

 T1 or T2 (n = 336)

3.184

2.336–4.329

< 0.001

1.626

1.127–2.347

0.009

 T3 or T4 (n = 186)

N stage

 N0 or NX (n = 507)

3.96

2.143–7.315

< 0.001

2.087

1.101–3.956

0.024

 N1 (n = 15)

M stage

 M0 or MX (n = 445)

4.378

3.199–5.992

< 0.001

2.52

1.752–3.625

< 0.001

 M1 (n = 77)

G grade

 Gx or G1 or G2 (n = 245)

2.681

1.901–3.782

< 0.001

1.638

1.129–2.377

0.009

 G3 or G4 (n = 277)

  1. aHazard ratio, estimated from Cox proportional hazard regression model
  2. bConfidence interval of the estimated HR
  3. cMultivariate models were adjusted for T, N, M stage, G grade, age and gender
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Journal of Translational Medicine

ISSN: 1479-5876

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