Fig. 1

Weighted gene co-expression network analysis (WGCNA) identified hub genes of renal cell carcinoma. A Analysis of Scale independence and mean connectivity for various soft-thresholding power. B The 26 gene dendrogram and module colors of DEGs based on TOM. C, D The eigengene adjacency heatmap and clustering of module eigengene to display the relationships between each module. E The relationships between 25 modules and clinical traits including T, N, M Stage and G grades. The pink module was selected as the most significant module. F The relationships between the genes in pink module and gene significance for M stage, T stage, Stage, and G grade. G The network of ten top hub genes by Cytoscape software. DEGs: differentially expressed genes; TOM: topological overlap matrix