Fig. 5
Tumor ADCmean, vMRI and cellular density after chemotherapy. ADC-map depicting a large tumor of the left uterine horn (A), photograph of tumor in situ immediately after MRI scanning, prior to excision (B) and histology section through a representative central part of tumor stained with HE (C). A-C are from the same mouse. Tumor ADCmean was significantly higher in treated animals compared to controls (D), the tumor volume (vMRI) (E) and the tumor cellular density (F) was significantly lower in the treated animals compared to the controls. Lines represent mean ± SD, and each dot represents a single sample. Significance was tested using a Mann–Whitney test. Longitudinal data for tumor ADCmean (G) and vMRI (H) is plotted for one mouse from each group. ADC apparent diffusion coefficient, vMRI tumor volume from MRI