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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: FGFR2 alteration as a potential therapeutic target in poorly cohesive gastric carcinoma

Fig. 4

a qRT-PCR for the TACC2-FGFR2 fusion transcript in MKN45, NUGC4 cells and corresponding TACC2-FGFR2-expressing cells. Data are presented as mean ± SEM. * means P < 0.05, ** means P < 0.01. b IHC of MKN45, NUGC4 cells and corresponding TACC2-FGFR2-expressing cells for FGFR2 protein. Scale bar = 50 µm. MKN45T: TACC2-FGFR2-expression MKN45 cells. NUGC4T: TACC2-FGFR2-expression NUGC4 cells. c Sensitivity of MKN45, NUGC4 cells transfected with TACC2-FGFR2 or control plasmids to FGFR2 inhibitors, including BGJ398, AZD4547 and Erdafitinib. MKN45T: TACC2-FGFR2-expression MKN45 cells. NUGC4T: TACC2-FGFR2-expression NUGC4 cells

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