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Table 1 Multivariate Cox regression analysis of OS and BCSS in METABRIC cohort

From: A novel immune subtype classification of ER-positive, PR-negative and HER2-negative breast cancer based on the genomic and transcriptomic landscape

Variables OS BCSS
HR (95% CI) P-value HR (95% CI) P-value
Age (years) 1.04 (1.03–1.06) 4.07e−10*** 1.00 (0.98–1.02) 0.87
Positive lymph nodes 1.07 (1.04–1.11) 4.92e−07*** 1.09 (1.06–1.13) 3.46e−08***
PAM50 subtype     
 Luminal Ref. Ref.
 Non-luminal 0.98 (0.71–1.34) 0.89 1.09 (0.71–1.67) 0.70
Immune subtypes     
 Cluster 1 0.60 (0.39–0.94) 0.024* 0.49 (0.27–0.87) 0.014*
 Cluster 2 Ref. Ref.
 Cluster 3 0.59 (0.37–0.92) 0.021* 0.31 (0.16–0.62) 0.00090***
 Cluster 4 0.76 (0.56–1.03) 0.075 0.65 (0.44–0.97) 0.034*
 Cluster 5 0.92 (0.58–1.47) 0.73 0.56 (0.28–1.14) 0.11
  1. Cluster 2 was used as the baseline for survival risk comparison for immune subtype variable. Luminal type was used as the baseline for survival risk comparison for PAM50 subtype.
  2. *P < 0.05; **P < 0.01; ***P < 0.001