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Table 1 Multivariate Cox regression analysis of OS and BCSS in METABRIC cohort

From: A novel immune subtype classification of ER-positive, PR-negative and HER2-negative breast cancer based on the genomic and transcriptomic landscape

Variables

OS

BCSS

HR (95% CI)

P-value

HR (95% CI)

P-value

Age (years)

1.04 (1.03–1.06)

4.07e−10***

1.00 (0.98–1.02)

0.87

Positive lymph nodes

1.07 (1.04–1.11)

4.92e−07***

1.09 (1.06–1.13)

3.46e−08***

PAM50 subtype

    

 Luminal

Ref.

Ref.

 Non-luminal

0.98 (0.71–1.34)

0.89

1.09 (0.71–1.67)

0.70

Immune subtypes

    

 Cluster 1

0.60 (0.39–0.94)

0.024*

0.49 (0.27–0.87)

0.014*

 Cluster 2

Ref.

Ref.

 Cluster 3

0.59 (0.37–0.92)

0.021*

0.31 (0.16–0.62)

0.00090***

 Cluster 4

0.76 (0.56–1.03)

0.075

0.65 (0.44–0.97)

0.034*

 Cluster 5

0.92 (0.58–1.47)

0.73

0.56 (0.28–1.14)

0.11

  1. Cluster 2 was used as the baseline for survival risk comparison for immune subtype variable. Luminal type was used as the baseline for survival risk comparison for PAM50 subtype.
  2. *P < 0.05; **P < 0.01; ***P < 0.001