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Table 3 Clinical characteristics between PARP1 low and high expression groups

From: Niraparib exhibits a synergistic anti-tumor effect with PD-L1 blockade by inducing an immune response in ovarian cancer

Characteristic

Total (n = 72)

PARP1 expression

PARP1 expression

P-value

Low

High

Age (year)

   

0.238

 < 55

36 (50.0)

21 (29.2)

15 (20.8)

 

 ≥ 55

36 (50.0)

15 (20.8)

21 (29.2)

 

FIGO stage (2014)

   

0.710

 I and II

8 (11.1)

3 (4.2)

5 (6.9)

 

 III and IV

64 (88.9)

33 (45.8)

31 (43.1)

 

Diameter (cm)

   

0.813

 < 8

40 (55.6)

19 (26.4)

21 (29.2)

 

 ≥ 8

32 (44.4)

17 (23.6)

15 (20.8)

 

Ascitic fluid

   

0.312

 Yes

23 (31.9)

9 (12.5)

14 (19.4)

 

 NO

49 (68.1)

27 (37.5)

22 (30.6)

 

CA125 (U/ml)

   

0.115

 < 35

4 (5.6)

0 (0.0)

4 (5.6)

 

 ≥ 35

68 (94.4)

36 (50.0)

32 (44.4)

 

PD-L1 expression

   

0.341

 Low

41 (56.9)

23 (31.9)

18 (25.0)

 

 High

31 (43.1)

13 (18.1)

18 (25.0)

 

CD8 expression (cancer tissue)

  

0.240

 Low

38 (52.8)

17 (23.6)

21 (29.2)

 

 High

34 (47.2)

19 (26.4)

15 (20.8)

 
  1. Values are n (%)
  2. FIGO, International Federation of Gynecology and Obstetrics; CA125, carbohydrate antigen; PARP1, poly-ADP-ribose polymerase 1; PD-L1, programmed death ligand 1