Fig. 4

Niraparib treatment enhances the proportion and function of T lymphocytes in the co-culture system. A The morphological characteristics of activated T cells. Scale bar:100 μm. B The sorting efficiency of CD8⁺T cells. C The cytotoxicity of T cells to tumor cells in different ratios. D, F Immune profiling was analyzed by flow cytometry of the co-culture system with different treatments of control, Niraparib, programmed cell death ligand 1 (PD-L1) blockade, and the combination. E, G Enzyme-linked immunosorbent assay (ELISA) analysis of the cytokine from the co-culture system supernatant with different treatments. All experiments were repeated three times. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01